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KMID : 0616120200510010036
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Korean Journal of Pharmacognosy
2020 Volume.51 No. 1 p.36 ~ p.40
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Cancer Cell Growth Inhibition of Lanostane-type Triterpenoids Isolated from Ganoderma gibbosum
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Kim Dong-Hwa
Lee Sang-Kook
Park Hee-Juhn
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Abstract
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The CHCl3 fraction of the MeOH extract of Ganoderma gibbosum (Ganodermataceae) exhibited cytotoxic activity on five cancer cell lines (MDA-MB-231, SK-hep1, A549, HCT116, and SNU638). Six highly oxygenated lanostane-type triterpenoids (lanostanoids) were isolated by column chromatography to test cytotoxicity on cancer cells. The five known lanostanoids were identified as gibbosic acids A, B, D, G, and H by comparison of molecular ion peaks with the literature data. The structure of a new lanostanoid, gibbosic acids I, was identified to be 3b,8b,15b,20S-tetrahydroxy-7,12,23-trioxolanost-9(11)-en-26-oic acid on the basis of NMR and MS spectroscopy. The three lanostanoids of gibbosic acids A, H, and I of the six isolates significantly suppressed the growth of cancer cells. In particular, the IC50 of gibbosic acid H was prominently low ranging from 2.64?6.56 μM.
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KEYWORD
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Ganoderma gibbosum, Ganodermataceae, Lanostanoids, Gibbosic acids, Cytotoxicity
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